Mayo Clinic studies have shown that 75% of chronic sinusitis sufferers saw improvement when treated with a topical fungicide. The Therapy is called topical antifungal therapy. An antifungal called Amphotericin B has already been approved by the FDA for other treatments and is normally administered to patients as an injection. For sinusitis cures it is made into a topical nasal spray and applied daily. The recommended dose is 100 micrograms/ml. This medication is generally not available in most pharmacies today. One must get the prescription filled through a compounding pharmacy such as Anazao. The best thing to do is find a physician who is trained in administering this therapy, and that doctor can no doubt explain how to obtain the medication prescribed.

In some people the eosinophiles do not react to fungi present in the nasal mucus, and these people generally do not have chronic sinusitis. Why the eosinophiles act differently in different people is not yet known. Also, it is difficult to administer a test which will tell if one person has this type of reaction occur in his body or not. However, this theory would explain why some people are chronic sinusitis sufferers even after extensive conventional treatments or sinus operations. The conventional therapies and surgeries to date have simply not addressed this issue, since it was not known prior to the Mayo Clinic studies and patient tests.